Platelet Rich Fibrin is blood plasma component used for induction of post-surgical wound healing after the oral surgical interventions: tooth extraction, implantation, etc. It is derived from venous blood sample of a patient, prepared and immediately injected into the wounded tissues of the same patient. Here the platelets play the major role. They release the growth factors and promote wound healing, tissue sealing, also improve regenerative properties of tissues and act as the mean to stop bleeding. After the use of platelet-rich fibrin, the bleeding stops, inflammation is reduced, wound healing is induced (bone mineralization and formation of new blood vessels are promoted) and the smaller scar is to be expected.